BrainXcan results for SCZ_PGC_2020
1 BrainXcan results
In this analysis, we tested 327 structural and diffusion MRI-derived phenotypes with cross validated spearman correlation >= 0.101.
For the main analysis we focused on 261 IDPs, which include 48 cortical volumes, 10 sub-cortical volumes, 13 sub-cortical gray matter volumes. In below, we show the overall number of IDP by IDP subtype in the main results.
| subtype | n |
|---|---|
| Brainstem | 1 |
| FA | 46 |
| Gray-Brainstem | 1 |
| Gray-Cerebellum | 27 |
| Gray-Cortical | 48 |
| Gray-Subcortical | 13 |
| ICVF | 44 |
| ISOVF | 13 |
| OD | 45 |
| PC-Cerebellum-1 | 1 |
| PC-Cortical-1 | 1 |
| PC-FA-TBSS-1 | 1 |
| PC-ICVF-TBSS-1 | 1 |
| PC-ISOVF-TBSS-1 | 1 |
| PC-OD-TBSS-1 | 1 |
| PC-Subcortical_GMvol-1 | 1 |
| PC-Subcortical_vol-1 | 1 |
| Subcortical | 10 |
| Total | 5 |
Among 261 IDPs (109 T1 and 109 diffusion MRI, including the subtype-specific PCs), 46 were significantly associated with SCZ_PGC_2020 (pval < \(1.92\times 10^{-4}\) = 0.05 / 261).
The top 2 associations for dMRI are
| IDP | subtype | region | side | zscore | pval | IDP -> Phenotype | Phenotype -> IDP | link |
|---|---|---|---|---|---|---|---|---|
| PC-ICVF-TBSS-1 | PC-ICVF-TBSS-1 | PC-ICVF-TBSS-1 | NA | -6.675 | 2.474e-11 | NA | NA | NA |
| PC-FA-TBSS-1 | PC-FA-TBSS-1 | PC-FA-TBSS-1 | NA | -6.207 | 5.404e-10 | NA | NA | NA |
The top 2 associations for T1 are
| IDP | subtype | region | side | zscore | pval | IDP -> Phenotype | Phenotype -> IDP | link |
|---|---|---|---|---|---|---|---|---|
| IDP-25020 | Subcortical | hippocampus | right | 8.325 | 8.409e-17 | 0.5322 | 0.7093 | MR plot |
| IDP-25847 | Gray-Cortical | frontal orbital cortex | right | 5.564 | 2.634e-08 | NA | NA | NA |
2 Visualization of associations in the brain
2.1 T1
2.2 dMRI
3 BrainXcan MR Figures
3.1 IDP-25020
Volume of right hippocampus (from T1 brain image)
