1 BrainXcan results

In this analysis, we tested 327 structural and diffusion MRI-derived phenotypes with cross validated spearman correlation >= 0.101.

For the main analysis we focused on 261 IDPs, which include 48 cortical volumes, 10 sub-cortical volumes, 13 sub-cortical gray matter volumes. In below, we show the overall number of IDP by IDP subtype in the main results.

subtype n
Brainstem 1
FA 46
Gray-Brainstem 1
Gray-Cerebellum 27
Gray-Cortical 48
Gray-Subcortical 13
ICVF 44
ISOVF 13
OD 45
PC-Cerebellum-1 1
PC-Cortical-1 1
PC-FA-TBSS-1 1
PC-ICVF-TBSS-1 1
PC-ISOVF-TBSS-1 1
PC-OD-TBSS-1 1
PC-Subcortical_GMvol-1 1
PC-Subcortical_vol-1 1
Subcortical 10
Total 5

Among 261 IDPs (109 T1 and 109 diffusion MRI, including the subtype-specific PCs), 46 were significantly associated with SCZ_PGC_2020 (pval < \(1.92\times 10^{-4}\) = 0.05 / 261).

The top 2 associations for dMRI are

IDP subtype region side zscore pval IDP -> Phenotype Phenotype -> IDP link
PC-ICVF-TBSS-1 PC-ICVF-TBSS-1 PC-ICVF-TBSS-1 NA -6.675 2.474e-11 NA NA NA
PC-FA-TBSS-1 PC-FA-TBSS-1 PC-FA-TBSS-1 NA -6.207 5.404e-10 NA NA NA

The top 2 associations for T1 are

IDP subtype region side zscore pval IDP -> Phenotype Phenotype -> IDP link
IDP-25020 Subcortical hippocampus right 8.325 8.409e-17 0.5322 0.7093 MR plot
IDP-25847 Gray-Cortical frontal orbital cortex right 5.564 2.634e-08 NA NA NA

2 Visualization of associations in the brain

2.1 T1

2.2 dMRI

3 BrainXcan MR Figures

3.1 IDP-25020

Volume of right hippocampus (from T1 brain image)